Table 2.
Interaction of weight‐loss interventions with PNPLA3 genotype in NAFLD or obesity
| Reference | Participants | Interventions | Study design | Main liver‐related outcome | PNPLA3 I148M association |
|---|---|---|---|---|---|
| Shen et al150 | Adults with NAFLD (N = 154) | 12‐mo dietician‐led programme or standard care | Parallel‐group | Greater decrease in liver fat a than standard care | Increased reduction in liver fat a in the intervention group |
| Krawczyk et al151 | Adults with suspected NAFLD (N = 143) | 4‐mo dietician‐led programme | Prospective, observational | Significant decrease in liver fat b from baseline | None |
| Krawczyk et al152 | Adults with obesity (N = 84) | Bariatric surgery | Prospective, observational | Decrease from baseline in liver fat c | Increased reduction in liver fat c |
| Palmer et al61 | Adults with obesity (N = 3473) | Bariatric surgery | Parallel‐group | Reduced BMI and serum triglycerides in surgery group only d | Increased reduction in BMI and serum triglycerides |
Abbreviations: BMI, body mass index; NAFLD, non‐alcoholic fatty liver disease.
a
Magnetic resonance spectroscopy.
b
Ultrasonography.
c
Magnetic resonance imaging proton density fat fraction.
d
Liver fat not assessed.