Table 1.
Serum proteins at baseline
| Chemokine | Median (quartile), ng/L | Reference,12 median, pg/mL† | Cytokine | Median (quartile), ng/L | Reference,13, 14 median, pg/mL† |
|---|---|---|---|---|---|
| Eotaxin | 98.0 (74.4–142.0) | 55.9 | GM‐CSF | 0.31 (0.24–0.39) | 0.18 |
| Eotaxin‐3 | 10.1 (6.5–16.6) | 8.2 | IFN‐γ | 3.90 (2.98–5.12) | 3.77 |
| IL‐8 (HA) | 662.0 (452.0–788.0) | 575.0 | IL‐1α | 0.10 (0.03–0.15) | 1.18 |
| IP‐10 | 319.0 (239.0–404.0) | 80.9 | IL‐1β | 0 (0–0.2) | 0.16 |
| MCP‐1 | 226.5 (188.0–274.0) | 118.0 | IL‐2 | 0.27 (0.16–0.33) | 0.52 |
| MCP‐4 | 103.5 (74.0–142.0) | 44.3 | IL‐4 | 0.06 (0.03–0.07) | ND |
| MDC | 1130.0 (828.0–1590.0) | 1350.0 | IL‐5 | 0.07 (0–0.47) | 0.28 |
| MIP‐1α | 14.8 (13.7–16.4) | 37.0 | IL‐6 | 0.79 (0.56–1.40) | 0.47 |
| MIP‐1β | 106.0 (72.4–137.0) | 53.1 | IL‐7 | 25.60 (18.0–32.80) | 0.92 |
| TARC | 287.5 (178.0–412.0) | 29.1 | IL‐8 | 10.85 (8.56–13.40) | 9.61 |
| IL‐10 | 0.28 (0.20–0.36) | 0.20 | |||
| Other | Median (quartile), ng/L | Reference, 5 GM, pg / mL † | IL‐12/IL‐23p40 | 56.00 (39.80–79.00) | 53.30 |
| BD‐2 | 5850.0 (1910.0–11 000.0) | 0.2 | IL‐12p70 | 0.20 (0.11–0.25) | 0.29 |
| IL‐13 | 0.79 (0.62–1.05) | 1.65 | |||
| IL‐15 | 2.22 (1.87–2.58) | 1.29 | |||
| IL‐16 | 224.00 (188.00–328.00) | 59.90 | |||
| IL‐17A | 3.44 (2.02–5.72) | 0.93 | |||
| TNF‐α | 2.42 (1.84–2.86) | 0.36 | |||
| TNF‐β | 0.34 (0.24–0.42) | 0.15 | |||
| VEGF‐A | 90.90 (57.40–157.00) | 9.62 |
†
Reference values refer to assay kit product insert and published report on healthy human subjects. pg/mL is equivalent to ng/L. Different detection antibodies were used for IL‐8 measurement in chemokine and cytokine panel according to manufacturers’ instructions. BD, β‐defensin; GM, geometric mean; GM‐CSF, granulocyte macrophage colony‐stimulating factors; IFN, interferon; IL, interleukin; IP, interferon‐γ‐inducible protein; MCP, monocyte chemoattractant protein; MDC, macrophage derived chemokine; MIP, macrophage inflammatory protein; ND, non‐detectable; TARC, thymus and activation‐regulated chemokine; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.