Figure 1.

Kinase dynamics. Shown is a hypothetical full‐length kinase with cis‐regulatory motifs. The N and C lobes of the kinase core are centered. Different types of intra‐ and intermolecular interactions affect kinase activities and/or conformations. Allosteric kinase inhibitors/activators bind to the kinase domain. ATP‐competitive inhibitors bind into the catalytic cleft. Allosteric protein transformations occur through PPI, cis‐regulatory elements (e.g., auto‐inhibitory modules) or pseudosubstrate binding sequences which may promote activity‐related kinase conformation states