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. 2020 Jun 26;20:275. doi: 10.1186/s12935-020-01332-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — LINC00261 overexpression inhibited the migration, invasion and related protein expressions in LC cells. a–c The migration of A549 and SPC-A1 cells was determined by wound-healing assay a. Magnification: 100×. The migration of A549 and SPC-A1 cells was calculated (b, c). d–f The invasion of A549 and SPC-A1 cells was calculated (d, e). The invaded cells (f) were subjected to transwell assay and observed under a microscope (Magnification: 200x). g–j The expression levels of MMP-3 and MMP-9 were determined by Western blot. GAPDH served as an internal control. ^**P < 0.001 vs. blank, ^##P < 0.001 vs NC. Blank: cells treated with transfection regent only. NC: pCDH-CMV empty plasmid. LINC00261: pCDH-CMV-LINC00261 overexpression plasmid. All experiments repeated independently in triplicate