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. 2020 Jun 26;20:275. doi: 10.1186/s12935-020-01332-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — LINC00261 overexpression inhibited tumor growth in vivo. a, b The xenograft tumor volume in nude mice from LINC00261 overexpression group (n = 3) and NC group (3 mice in each group). c Photographs of tumors at day 30 after LINC00261 transfected A549 and SPC-A1 cells injected into nude mice (3 mice in each group). d, e The tumor weight g in nude mice from LINC00261 overexpression group (n = 3) and NC group (3 mice in each group). f–i The expression levels of FOXO1 were increased in LINC00261 overexpression group, which was detected by IHC. j–k The expression levels of miR-1269a were significantly decreased in LINC00261 overexpression group, which was detected by RT-qPCR. ^**P < 0.001 vs. NC. NC: pCDH-CMV empty plasmid. LINC00261: pCDH-CMV-LINC00261 overexpression plasmid. All experiments repeated independently in triplicate