Fig. 5.

Genetic ablation of Shp2 in lung epithelial cells or pharmacological inhibition of Shp2 alleviates the CS- and CSE-induced pro-MMP-9 (gelatinase B) expression and MMP-9 activity in lung tissues. a-c Genetic ablation of Shp2 in lung epithelial cells or Shp2 inhibitor – PHPS1 (3 mg/kg, i.p injection) alleviates the CS-induced pro-MMP-9 (gelatinase B) expression and MMP-9 activity in lung tissues, assessed by gelatin zymography. n = 8 mice/per group. ^#p < 0.05, ^##p < 0.01, compared with control (WT mice), ^*p < 0.05, ^**p < 0.01 compared with control (WT mice) with CS exposure. Data are presented as the mean ± SEM. Statistical significance is determined by one-way ANOVA followed by the Student-Newman-Keuls test