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BTK degradation profile in NAMALWA cells for PROTACs SJF608 and SJF620. (A) Structures of PROTAC derivatives screened for cellular degradation of BTK. (B) Representative immunoblots showing degradation of BTK relative to GAPDH loading control. All compounds were screened at indicated concentrations in biological duplicate in NAMALWA. (C) Quantitation of DC50 and DMax values of these compounds by non-linear regression.
