Table 2.
Results of an overrepresentation analysis on the identified proteins in unstimulated equine articular chondrocytes carried out using the Reactome resource. The analysis is based on a statistical (hypergeometric distribution) test that determines whether certain Reactome pathways are over-represented (enriched) in the submitted data. This test produces a probability score, which is corrected for false discovery rate using the Benjamani-Hochberg method. The 25 most relevant pathways sorted by p-value are shown. Table extracted from Reactome Pathway Analysis Report
| Pathway name | Entities | Reactions | ||||
|---|---|---|---|---|---|---|
| found | ratio | p-value | FDRa | found | ratio | |
| Neutrophil degranulation | 66 / 480 | 0.033 | 1.11e-16 | 1.51e-13 | 10 / 10 | 8.01e-04 |
| Formation of the cornified envelope | 33 / 138 | 0.01 | 7.77e-16 | 5.29e-13 | 11 / 27 | 0.002 |
| Extracellular matrix organization | 47 / 329 | 0.023 | 1.37e-13 | 6.24e-11 | 181 / 318 | 0.025 |
| Integrin cell surface interactions | 21 / 86 | 0.006 | 1.02e-10 | 3.47e-08 | 46 / 54 | 0.004 |
| Axon guidance | 59 / 584 | 0.04 | 1.33e-10 | 3.61e-08 | 182 / 297 | 0.024 |
| Keratinization | 33 / 226 | 0.016 | 3.80e-10 | 8.64e-08 | 18 / 34 | 0.003 |
| Developmental Biology | 92 / 1207 | 0.084 | 2.00e-09 | 3.88e-07 | 206 / 511 | 0.041 |
| Platelet degranulation | 24 / 137 | 0.009 | 3.30e-09 | 5.61e-07 | 8 / 11 | 8.81e-04 |
| Response to elevated platelet cytosolic Ca2+ | 24 / 144 | 0.01 | 8.45e-09 | 1.28e-06 | 8 / 14 | 0.001 |
| Platelet activation, signaling and aggregation | 35 / 293 | 0.02 | 1.76e-08 | 2.40e-06 | 42 / 114 | 0.009 |
| Interleukin-12 family signaling | 18 / 96 | 0.007 | 1.13e-07 | 1.39e-05 | 33 / 114 | 0.009 |
| EPH-Ephrin signaling | 18 / 101 | 0.007 | 2.35e-07 | 2.66e-05 | 52 / 56 | 0.004 |
| Innate Immune System | 91 / 1328 | 0.092 | 3.22e-07 | 3.35e-05 | 174 / 696 | 0.056 |
| Cell junction organization | 17 / 94 | 0.007 | 4.15e-07 | 4.02e-05 | 26 / 37 | 0.003 |
| Signaling by Receptor Tyrosine Kinases | 48 / 554 | 0.038 | 6.84e-07 | 6.03e-05 | 261 / 657 | 0.053 |
| Cell-Cell communication | 20 / 133 | 0.009 | 7.12e-07 | 6.03e-05 | 36 / 60 | 0.005 |
| Hemostasis | 63 / 821 | 0.057 | 7.54e-07 | 6.03e-05 | 83 / 327 | 0.026 |
| Non-integrin membrane-ECM interactions | 13 / 61 | 0.004 | 1.64e-06 | 1.23e-04 | 16 / 22 | 0.002 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 14 / 73 | 0.005 | 2.21e-06 | 1.56e-04 | 7 / 36 | 0.003 |
| Interleukin-12 signaling | 15 / 84 | 0.006 | 2.29e-06 | 1.56e-04 | 9 / 56 | 0.004 |
| EPH-ephrin mediated repulsion of cells | 12 / 55 | 0.004 | 3.23e-06 | 2.06e-04 | 9 / 9 | 7.21e-04 |
| Syndecan interactions | 9 / 29 | 0.002 | 3.47e-06 | 2.06e-04 | 9 / 15 | 0.001 |
| Degradation of the extracellular matrix | 20 / 148 | 0.01 | 3.49e-06 | 2.06e-04 | 53 / 105 | 0.008 |
| Immune System | 156 / 2822 | 0.196 | 7.43e-06 | 4.16e-04 | 344 / 1597 | 0.128 |
| L1CAM interactions | 18 / 130 | 0.009 | 7.70e-06 | 4.16e-04 | 21 / 54 | 0.004 |
aFalse Discovery Rate