Fig. 4.

CCL1 blockade attenuated the severity of lung histopathology score and fibrosis while maintaining protective effects against CGVHD in the skin. a, b Representative photomicrographs of histopathological changes from non-GVHD controls, Scl-GVHD, Scl-GVHD + hAD MSCs + αIgG, and Scl-GVHD + hAD MSCs + αCCL1 groups on day 20. The sections were stained with H&E (a) or Masson’s trichrome (b). c CD3⁺ T cell and CD68⁺ macrophage infiltration of lung tissues was examined in each group. Each value indicates the mean ± SEM of 4–9 mice per group. *P < 0.05; **P < 0.01, ***P < 0.001