Table 1.
Characteristics* of participants by quintile of the lipoprotein insulin resistance score (n = 980)
| Characteristics | Q1 (n = 198) | Q2 (n = 200) | Q3(n = 194) | Q4(n = 199) | Q5 (n = 184) | P-value |
|---|---|---|---|---|---|---|
| Age at blood draw (y) | 45.0 (35.0–75.5) | 46.0 (34.0–61.3) | 48.0 (39.3–61.8) | 50.0 (40.5–63.0) | 49.5 (40.0–61.3) | 0.008 |
| Sex | ||||||
| Male | 43 (22) | 82 (41) | 110 (57) | 106 (53) | 125 (68) | < 0.001 |
| BMI (kg/m2) | 23.9 (21.6–27.4) | 25.6 (23.0–28.9) | 27.8 (25.5–30.9) | 29.4 (27.0–32.5) | 31.0 (27.8–33.8) | < 0.001 |
| Waist circumference (cm) | ||||||
| Male | 88.0 (83.0–93.5) | 93.5 (89.0–100.0) | 98.0 (91.0–105.0) | 103.0 (97.0–111.0) | 105.0 (97.0–113.0) | < 0.001 |
| Female | 80.0 (74.0–89.5) | 86.0 (79.0–94.0) | 94.5 (85.8–105.3) | 100.0 (91.0–110.0) | 109.0 (96.5–118.0) | < 0.001 |
| Fasting glucose (mg/dl) | 92.0 (89.0–98.0) | 94.0 (90.0–101.0) | 97.5 (93.0–105.0) | 101.0 (96.0–108.0) | 104.0 (98.0–114.0) | < 0.001 |
| Fasting insulin (mU/L) | 9.0 (7.0–11.0) | 10.0 (8.0–12.0) | 12.0 (9.0–15.0) | 15.0 (11.0–20.0) | 16.0 (12.0–22.5) | < 0.001 |
| HOMA-IR | 2.1 (1.6–2.7) | 2.5 (1.9–2.9) | 2.8 (2.2–3.9) | 3.6 (2.7–5.2) | 4.1 (3.2–6.5) | < 0.001 |
| Center | 0.3 | |||||
| Minnesota | 106 (54) | 95 (48) | 85 (44) | 105 (53) | 90 (49) | |
| Utah | 92 (46) | 105 (52) | 109 (56) | 94 (47) | 94 (51) | |
| Diabetes | < 0.001 | |||||
| Yes | 6 (3) | 10 (5) | 9 (5) | 23 (12) | 26 (14) | |
| No | 192 (97) | 190 (95) | 184 (95) | 176 (88) | 158 (86) | |
| Metabolic Syndrome | 0.054 | |||||
| Yes | 76 (38) | 82 (41) | 64 (33) | 55 (28) | 63 (34) | |
| No | 122 (62) | 118 (59) | 130 (67) | 144 (72) | 121 (66) | |
* Median (IQRs) or n (%)
Abbreviations: HOMA-IR Homeostatic model assessment-insulin resistance