Table 4.
Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) LPIR associated lipids which are also associated with homeostatic model assessment-insulin resistance (HOMA-IR) in GOLDN compared to HOMA_IR associated lipid species in the HAPI Heart study
| GOLDN study | HAPI Heart Study | |||||
|---|---|---|---|---|---|---|
| Metabolites† | β | SE | FDR-correctedP-value‡ | β | SE | FDR-correctedP-value‡ |
| CE (18:1) | − 0.137 | 0.014 | 8.41E-21 | −0.177 | 0.036 | 9.70E-06 |
| CE (18:2) | −0.105 | 0.015 | 5.14E-12 | −0.122 | 0.038 | 0.0043 |
| CE (20:3) | −0.057 | 0.015 | 0.00029 | −0.148 | 0.034 | 9.17E-05 |
| CE (20:4) | −0.083 | 0.015 | 5.69E-08 | −0.114 | 0.039 | 0.0086 |
| CE (22:6) | −0.070 | 0.014 | 2.65E-06 | −0.091 | 0.039 | 0.0387 |
| Ceramide (d40:0) | 0.093 | 0.012 | 4.20E-13 | 0.113 | 0.035 | 0.0033 |
| Ceramide (d42:0) | 0.083 | 0.012 | 1.59E-10 | 0.102 | 0.036 | 0.0128 |
| DG (32:1) | 0.105 | 0.014 | 3.41E-13 | 0.158 | 0.028 | 2.90E-07 |
| DG (34:1) | 0.115 | 0.013 | 8.72E-17 | 0.184 | 0.031 | 1.74E-07 |
| DG (34:2) | 0.092 | 0.014 | 1.02E-10 | 0.228 | 0.037 | 6.03E-08 |
| DG (36:2) | 0.070 | 0.014 | 1.76E-06 | 0.125 | 0.034 | 9.00E-04 |
| DG (36:3) | 0.054 | 0.014 | 0.00031 | 0.097 | 0.034 | 0.0123 |
| DG (38:5) | 0.061 | 0.014 | 4.79E-05 | 0.184 | 0.036 | 4.80E-06 |
| GlcCer (d42:2) | −0.052 | 0.015 | 0.00078 | −0.102 | 0.04 | 0.0233 |
| LPC (18:1) | −0.051 | 0.014 | 0.00070 | −0.112 | 0.037 | 0.0067 |
| LPC (18:2) | −0.038 | 0.014 | 0.01010 | −0.081 | 0.033 | 0.0291 |
| LPC (20:1) | −0.044 | 0.013 | 0.00196 | −0.149 | 0.035 | 1.00E-04 |
| LPC (22:5) | −0.046 | 0.015 | 0.00359 | −0.102 | 0.04 | 0.023 |
| PC (34:4) | 0.039 | 0.014 | 0.01240 | 0.088 | 0.036 | 0.0319 |
| PC (37:3) | 0.033 | 0.015 | 0.04254 | −0.093 | 0.039 | 0.0345 |
| PC (37:4) | −0.048 | 0.015 | 0.00292 | −0.095 | 0.038 | 0.0281 |
| PC (38:3) | 0.061 | 0.015 | 9.58E-05 | 0.176 | 0.035 | 5.78E-06 |
| PC (40:4) | 0.040 | 0.015 | 0.01475 | 0.171 | 0.038 | 5.31E-05 |
| PC (40:6) B | 0.031 | 0.014 | 0.04002 | 0.1 | 0.038 | 0.0196 |
| PC (42:5) | 0.033 | 0.014 | 0.04006 | 0.105 | 0.039 | 0.0184 |
| PC (42:6) | 0.042 | 0.015 | 0.00878 | 0.135 | 0.037 | 0.001 |
| PC (o-32:0) | −0.040 | 0.015 | 0.01473 | −0.181 | 0.035 | 2.45E-06 |
| PC (p-32:0) or PC (o-32:1) | −0.058 | 0.015 | 0.00031 | −0.221 | 0.036 | 4.60E-08 |
| PC (p-34:0) or PC (o-34:1) | −0.095 | 0.014 | 9.43E-11 | −0.244 | 0.034 | 3.85E-10 |
| PC (p-34:1) or PC (o-34:2) B | −0.141 | 0.013 | 4.08E-24 | −0.302 | 0.032 | 6.01E-17 |
| PC (p-34:2) or PC (o-34:3) | −0.090 | 0.015 | 4.09E-09 | −0.252 | 0.035 | 2.28E-10 |
| PC (p-36:1) or PC (o-36:2) A | −0.092 | 0.013 | 0.02546 | −0.19 | 0.039 | 1.31E-05 |
| PC (p-36:2) or PC (o-36:3) | −0.044 | 0.015 | 0.00736 | −0.177 | 0.036 | 1.13E-05 |
| PC (p-36:4) or PC (o-36:5) | −0.054 | 0.014 | 0.00044 | −0.172 | 0.038 | 4.84E-05 |
| PC (p-38:4) or PC (o-38:5) A | −0.058 | 0.015 | 0.00032 | −0.136 | 0.038 | 0.0013 |
| PC (p-38:4) or PC (o-38:5) B | −0.068 | 0.014 | 6.66E-06 | −0.218 | 0.036 | 8.86E-08 |
| PC (p-40:1) or PC (o-40:2) | −0.035 | 0.015 | 0.03400 | −0.115 | 0.039 | 0.0082 |
| PC (p-40:3) or PC (o-40:4) | −0.042 | 0.015 | 0.00917 | −0.157 | 0.037 | 1.00E-04 |
| PC (p-40:4) or PC (o-40:5) | −0.055 | 0.015 | 0.00049 | −0.198 | 0.037 | 1.54E-06 |
| PC (p-40:6) or PC (o-40:7) B | −0.031 | 0.014 | 0.04752 | −0.186 | 0.038 | 1.28E-05 |
| PC (p-42:2) or PC (o-42:3) | −0.069 | 0.014 | 4.93E-06 | −0.173 | 0.04 | 7.84E-05 |
| PC (p-42:3) or PC (o-42:4) | −0.053 | 0.015 | 0.00089 | −0.111 | 0.04 | 0.0123 |
| PC (p-42:4) or PC (o-42:5) | −0.060 | 0.015 | 0.00012 | −0.201 | 0.037 | 1.12E-06 |
| PC (p-42:5) or PC (o-42:6) A | −0.045 | 0.015 | 1.07E-06 | −0.168 | 0.04 | 1.00E-04 |
| PC (p-44:4) or PC (o-44:5) | −0.053 | 0.015 | 0.00063 | −0.187 | 0.036 | 3.09E-06 |
| PC (p-44:5) or PC (o-44:6) | −0.058 | 0.015 | 0.00039 | −0.121 | 0.036 | 0.0028 |
| PE (34:1) | 0.080 | 0.013 | 1.07E-08 | 0.116 | 0.033 | 0.0017 |
| PE (34:2) | 0.073 | 0.014 | 2.10E-06 | 0.129 | 0.032 | 3.00E-04 |
| PE (36:1) | 0.114 | 0.014 | 2.66E-15 | 0.127 | 0.027 | 1.76E-05 |
| PE (36:2) | 0.104 | 0.014 | 1.40E-13 | 0.135 | 0.029 | 2.09E-05 |
| PE (36:3) | 0.069 | 0.014 | 4.25E-06 | 0.06 | 0.026 | 0.04 |
| PE (36:4) | 0.034 | 0.013 | 0.02289 | 0.092 | 0.035 | 0.0196 |
| PE (38:4) B | 0.052 | 0.012 | 6.71E-05 | 0.084 | 0.038 | 0.0483 |
| PE (38:6) | 0.040 | 0.013 | 0.00539 | 0.077 | 0.034 | 0.0476 |
| PE (p-40:5) or PE (o-40:6) | −0.037 | 0.014 | 0.01636 | −0.1 | 0.042 | 0.0348 |
| SM (d38:2) | −0.058 | 0.014 | 0.00015 | −0.171 | 0.033 | 2.43E-06 |
| SM (d39:2) | −0.074 | 0.014 | 3.75E-07 | −0.18 | 0.034 | 1.54E-06 |
| SM (d40:2) B | −0.056 | 0.015 | 0.00048 | −0.157 | 0.037 | 1.00E-04 |
| SM (d40:3) | −0.043 | 0.014 | 0.00566 | −0.197 | 0.036 | 1.27E-06 |
| SM (d42:0) | 0.040 | 0.014 | 0.00740 | 0.098 | 0.038 | 0.023 |
| SM (d42:2) B | −0.038 | 0.014 | 0.01437 | −0.167 | 0.037 | 4.84E-05 |
| SM (d42:3) | −0.054 | 0.013 | 0.00010 | −0.224 | 0.036 | 2.54E-08 |
| TG (40:1) | 0.124 | 0.014 | 6.21E-17 | 0.057 | 0.024 | 0.0336 |
| TG (42:0) | 0.117 | 0.015 | 4.86E-14 | 0.08 | 0.024 | 0.0024 |
| TG (42:1) | 0.118 | 0.015 | 1.01E-14 | 0.082 | 0.024 | 0.0017 |
| TG (44:1) | 0.132 | 0.014 | 6.00E-19 | 0.101 | 0.024 | 1.00E-04 |
| TG (44:2) | 0.133 | 0.014 | 6.13E-19 | 0.116 | 0.024 | 1.50E-05 |
| TG (46:0) | 0.142 | 0.014 | 4.69E-23 | 0.092 | 0.024 | 6.00E-04 |
| TG (46:1) | 0.135 | 0.014 | 1.33E-20 | 0.131 | 0.024 | 8.49E-07 |
| TG (46:2) | 0.132 | 0.014 | 5.69E-19 | 0.136 | 0.025 | 7.46E-07 |
| TG (48:0) | 0.138 | 0.014 | 3.64E-22 | 0.147 | 0.028 | 1.54E-06 |
| TG (49:0) | 0.139 | 0.014 | 3.00E-22 | 0.076 | 0.024 | 0.005 |
| TG (49:1) | 0.133 | 0.014 | 2.06E-20 | 0.115 | 0.025 | 2.17E-05 |
| TG (49:3) | 0.107 | 0.014 | 6.96E-13 | 0.136 | 0.03 | 3.87E-05 |
| TG (50:1) | 0.132 | 0.014 | 8.68E-21 | 0.183 | 0.027 | 1.77E-09 |
| TG (50:2) | 0.121 | 0.013 | 2.59E-18 | 0.189 | 0.029 | 1.31E-08 |
| TG (51:1) | 0.129 | 0.014 | 1.29E-19 | 0.11 | 0.024 | 3.57E-05 |
| TG (51:2) | 0.112 | 0.014 | 3.28E-15 | 0.133 | 0.029 | 3.79E-05 |
| TG (51:3) | 0.091 | 0.014 | 5.44E-10 | 0.125 | 0.034 | 9.00E-04 |
| TG (51:4) | 0.076 | 0.015 | 1.09E-06 | 0.109 | 0.034 | 0.0041 |
| TG (51:5) | 0.071 | 0.015 | 5.72E-06 | 0.147 | 0.036 | 3.00E-04 |
| TG (52:1) | 0.143 | 0.013 | 2.38E-25 | 0.15 | 0.024 | 3.79E-08 |
| TG (52:2) | 0.062 | 0.014 | 4.71E-05 | 0.163 | 0.034 | 1.28E-05 |
| TG (52:3) | 0.085 | 0.014 | 3.51E-09 | 0.142 | 0.035 | 3.00E-04 |
| TG (52:4) | 0.072 | 0.014 | 1.78E-06 | 0.199 | 0.035 | 2.51E-07 |
| TG (52:6) | 0.065 | 0.015 | 2.81E-05 | 0.217 | 0.037 | 1.94E-07 |
| TG (53:1) | 0.138 | 0.014 | 1.08E-22 | 0.098 | 0.023 | 2.00E-04 |
| TG (53:3) | 0.083 | 0.014 | 1.74E-08 | 0.11 | 0.033 | 0.0032 |
| TG (53:4) | 0.073 | 0.014 | 1.79E-06 | 0.125 | 0.036 | 0.002 |
| TG (53:5) | 0.055 | 0.015 | 0.00048 | 0.118 | 0.035 | 0.0024 |
| TG (54:0) | 0.111 | 0.015 | 2.43E-13 | 0.084 | 0.034 | 0.0309 |
| TG (54:1) | 0.142 | 0.014 | 1.47E-23 | 0.123 | 0.024 | 2.45E-06 |
| TG (54:3) | 0.060 | 0.014 | 7.07E-05 | 0.095 | 0.035 | 0.0177 |
| TG (55:3) | 0.083 | 0.014 | 2.77E-08 | 0.081 | 0.03 | 0.0168 |
| TG (56:2) | 0.125 | 0.014 | 1.82E-18 | 0.141 | 0.029 | 8.44E-06 |
| TG (56:4) | 0.059 | 0.015 | 0.00019 | 0.1 | 0.035 | 0.0119 |
| TG (56:7) B | 0.063 | 0.014 | 1.78E-05 | 0.127 | 0.036 | 0.0013 |
| TG (56:8) B | 0.061 | 0.014 | 4.45E-05 | 0.115 | 0.036 | 0.0039 |
| TG (57:2) | 0.127 | 0.014 | 1.39E-18 | 0.091 | 0.025 | 0.0013 |
| TG (58:1) | 0.109 | 0.014 | 1.12E-13 | 0.167 | 0.031 | 1.47E-06 |
| TG (58:2) | 0.112 | 0.014 | 3.38E-14 | 0.163 | 0.037 | 5.74E-05 |
| TG (58:3) | 0.097 | 0.014 | 8.15E-11 | 0.149 | 0.042 | 0.0015 |
| TG (58:5) | 0.073 | 0.015 | 3.67E-06 | 0.128 | 0.035 | 0.001 |
| TG (58:6) | 0.071 | 0.014 | 2.42E-06 | 0.14 | 0.034 | 2.00E-04 |
| TG (60:2) | 0.092 | 0.014 | 4.06E-10 | 0.128 | 0.036 | 0.0014 |
*Adjusted for age, sex, BMI, center and family relationship
† Metabolite values were rank-inverse transferred
‡ P-values were FDR corrected to account for multiple comparisons. Results are shown for significant metabolites (FDR-adjusted P < 0.05). study
Abbreviations: SE Standard Error, CE Cholesteryl ester, DG Diglycerides, LPC Lysophosphatidylcholine, PC Phosphatidylcholine, PE Phosphoethanolamine, SM Sphingomyelin, TG Triglycerides