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. 2020 Jun 26;12:94. doi: 10.1186/s13148-020-00883-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Progression-free survival in two cohorts of metastasized melanoma patients treated with immune checkpoint blockade in association to PD-L2 methylation and PD-L2 mRNA expression. Kaplan–Meier analysis of progression-free survival in metastasized melanoma patients stratified according to cg07211259 methylation (a) and PD-L2 mRNA expression (b) levels in pre-treatment samples. Patient samples were dichotomized based on optimized cutoffs. Follow-up data was available from N = 129 (methylation cohort) and N = 121 (mRNA expression cohort obtained from Liu et al. [25]) patients, respectively