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. 2020 Jun 26;11:250. doi: 10.1186/s13287-020-01753-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Experiments in normal glucose DMEM (5.5 mM). a, b Effect of sucralose on reactive oxygen species (ROS) accumulation has been tested in vitro by Mitosox staining (n = 3). Accumulation of ROS in human mesenchymal stromal cells (MSCs) increased secondary to sucralose exposure in a dose-dependent manner. a shows florescence with Mitosox Red in presence of different concentrations of sucralose by confocal microscopy. b shows relative florescence measured from MSCs exposed to different concentrations of sucralose. c Shows MSC viability following exposure to sucralose. Viability of cells (N = 2) decreased, when exposed to sucralose in a dose-dependent manner in the presence of normal glucose concentrations in culture medium. d Effects on antioxidants and adipogenic genes in a dose-dependent manner when MSCs were exposed to sucralose in the presence of normal glucose. Statistical analysis: unpaired t test was performed by considering NG (normal glucose) as control (N = 2)