Table 4.

Geometric means ratio of plasma RBT and d-RBT concentrations after the administration of RBT (150 mg or 300 mg EOD) combined with lopinavir/ritonavir (200 mg/50 mg)

Plasma RBT concentration (ng/mL)	GMR (150 mg RBT/300 mg RBT)	95%CI		pvalue
Cmax	0.473	0.264	0.847	0.015
Tmax	0.841	0.464	1.522	0.540
AUC0–12h	0.510	0.315	0.823	0.009
Plasma d-RBT concentration (ng/mL)
Cmax	0.544	0.303	0.977	0.042
Tmax	1.254	0.615	2.559	0.507
AUC0–12	0.597	0.333	0.830	0.009

Abbreviations: GMR geometric means ratio, RBT rifabutin, d-RBT 25-O-desacetyl-rifabutin, EOD every other day