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. 2020 Jun 26;20:449. doi: 10.1186/s12879-020-05169-2

Table 5.

Proportion and grade of most frequent adverse events observed in each arm of the study

Clinical Arm A Arm B
Adverse Events Grade Adverse Events Grade
Grade 1 Grade 2 Grade 3 Grade 4 Grade 1 Grade 2 Grade 3 Grade 4
Asthenia/fatigue 5/9 4 1 3/7 2 1
Headaches 4/9 3 1 6/7 5 1
anorexia 7/9 7 3/7 3
diarrhoea 1/9 1 1 2/7 2
Nausea/vomiting 1/9 1 3/7 3
Arthralgia 1/9 1 5/7 1 3 1
Insomnia 6/9 4 2 3/7 2 1
vertigo 5/9 4 1 0/7
Skin rash 5/9 4 1 2/7 1 1
Death 1/9 1 1/7 1
Laboratory
 Anaemia 9/9 2 3 2 2 7/7 3 2 1 1
 Leukopenia 3/9 3 1/7 1
 Neutropenia 1/9 1 2/7 1 1
 Thrombopenia 0/9 1/7 2
 ALT elevated 6/9 4 2 0/7
 ASAT elevated 7/9 6 1 3/7 3
 Amylasemia elevated 3/9 3 2/7 2
 Bilirubinemia T elevated 4/9 4 5/7 3 2