Table 1.
Baseline characteristics
| Parameters | Intracoronary prourokinase group (N = 25) | Control group (N = 25) | P value |
|---|---|---|---|
| Age, mean ± SD, years | 59.48 ± 14.36 | 60.96 ± 12.56 | 0.700 |
| Male, No. (%) | 21 (80.8) | 22 (88.0) | 0.440 |
| BMI, mean ± SD, kg/m2 | 25.69 ± 2.94 | 25.45 ± 2.89 | 0.769 |
| Current smoker, No. (%) | 12 (48.0) | 13 (52.0) | 0.777 |
| Angina history, No. (%) | 13 (52.0) | 11 (44.0) | 0.571 |
| Hypertension, No. (%) | 17 (47.2) | 19 (52.8) | 0.529 |
| Diabetes mellitus, No. (%) | 8 (32.0) | 6 (24.0) | 0.528 |
| Dyslipidemia, No. (%) | 8 (30.0) | 5 (20.0) | 0.333 |
| Heart rate, mean ± SD, bpm | 73.24 ± 14.22 | 77.40 ± 16.32 | 0.341 |
| SBP, mean ± SD, mmHg | 130.36 ± 24.31 | 131.72 ± 24.93 | 0.846 |
| DBP, mean ± SD, mmHg | 77.76 ± 15.56 | 81.92 ± 18.13 | 0.388 |
| Killip grade, No. (%) | 0.465 | ||
| I | 10 (40.0) | 14 (56.0) | |
| II | 11 (44.0) | 9 (36.0) | |
| III | 4 (16.0) | 2 (8.0) | |
| Creatinine, mean ± SD, μmoI/L | 85.32 ± 28.85 | 79.56 ± 16.23 | 0.389 |
| GRF, mean ± SD, ml/min | 91.17 ± 26.26 | 96.62 ± 20.49 | 0.418 |
| RBC, mean ± SD, 10^9/L | 4.54 ± 0.52 | 4.51 ± 0.55 | 0.845 |
| NLR, mean ± SD | 8.20 ± 5.53 | 8.19 ± 6.94 | 0.996 |
| PLT, mean ± SD, 10^9/L | 191.53 ± 91.73 | 220.92 ± 46.34 | 0.159 |
| MPV, mean ± SD, fL | 7.70 ± 2.70 | 8.43 ± 1.89 | 0.222 |
| Medications prior to PCI, No.(%) | |||
| Aspirin | 25 (100.0) | 25 (100.0) | 1.000 |
| Ticagrelor | 25 (100.0) | 25 (100.0) | 1.000 |
| Statins | 25 (100.0) | 25 (100.0) | 1.000 |
| Heparin | 25 (100.0) | 25 (100.0) | 1.000 |
| IIb/IIIa inhibitor | 18 (72.0) | 14 (56.0) | 0.239 |
| Intravenous nitroglycerin | 15 (60.0) | 18 (72.0) | 0.370 |
| Medications at discharge, No.(%) | |||
| ACEI | 16 (64.0) | 20 (80.0) | 0.208 |
| B-blocker | 14 (56.0) | 18 (72.0) | 0.239 |
| Statins | 25 (100.0) | 25 (100.0) | 1.000 |
| DAPT | 25 (100.0) | 25 (100.0) | 1.000 |
Differences between two groups were determined by Student’s t-test, Mann-Whitney U test, Chi-squared test or Fisher’s exact test, as appropriate. SD standard deviation, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, GRF glomerular filtration rate, RBC red blood count, NLR neutrophiltolymphocyte ratio, PLT platelet count, MPV mean platelet volume, PCI percutaneous coronary intervention, ACEI angiotension-converting enzyme, DAPT dual anti-platelet therapy