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Compounds 6 and 10 potently reduced protein levels of EGFR mutants and inhibited downstream signaling in lung cancer cells. NSCLC cell lines HCC-827 (A) and H3255 (B) were cultured to 80% confluent and then switched to a serum-free medium for 8 h before treating with indicated concentrations of the compounds for another 16 h. EGFR e19d: EGFR mutant with exon 19 deletion; EGFR L858R: EGFR L858R single point mutant; Gef: gefitinib (parental EGFR inhibitor; 1 μM); 1k: 1000; 10k: 10 000.
