Table 3.

Kinetic isotope effects for hydroxylation of mefenamic acid by P450 BM3 M11: ratios of non‐deuterated (D₀) vs. deuterated (D_11/12) hydroxy metabolites formed in incubations of P450 BM3 M11 with an equimolar mixture of deuterated (D_12/13) and non‐deuterated mefenamic acid (total concentration 750 μm).

T [K]	3′‐OH‐MF	4′‐OH‐MF	5‐OH‐MF
278	3.84±0.20	0.65±0.002	1.08±0.02
288	4.35±0.20	0.66±0.001	1.02±0.03
298	3.78±0.48	0.65±0.002	1.06±0.01
308	3.58±0.55	0.79±0.006	1.00±0.01