Table 4.
Prevalence of Co‐Pathologies by Pathological Diagnosis
| N | Pathological diagnosis | ||||||
|---|---|---|---|---|---|---|---|
| FTLD‐TDP | FTLD‐TAU | AD | LBD | FUS | |||
| 53 | 42 | 35 | 3 | 8 | |||
| COPATHOLOGY | TDP‐43 pathology | n | 53 | 8 | 14 | 1 | 0 |
| % | 100 | 19 | 40 | 33 | 0 | ||
| FTD‐MND copathology* | n | 7 | NA | NA | NA | 1 | |
| % | 13 | NA | NA | NA | 13 | ||
| Braak stage tau 1–2 | n | 30 | NA | 0 | 2 | 4 | |
| % | 57 | 0 | 67 | 50 | |||
| Braak stage tau 3–4 | n | 8 | NA | 3 | 0 | 0 | |
| % | 15 | 9 | 0 | 0 | |||
| Braak stage tau 5–6 | n | 2 | NA | 32 | 0 | 0 | |
| % | 4 | 91 | 0 | 0 | |||
| Aß plaques Thal 1–2 | n | 22 | 17 | 2 | 3 | 1 | |
| % | 42 | 40 | 6 | 100 | 13 | ||
| Aß plaques Thal 3 | n | 9 | 3 | 1 | 0 | 0 | |
| % | 17 | 7 | 3 | 0 | 0 | ||
| Aß plaques Thal 4–5 | n | 4 | 1 | 32 | 0 | 0 | |
| % | 8 | 2 | 91 | 0 | 0 | ||
| Lewy bodies | n | 1 | 0 | 19 | 3 | 1 | |
| % | 2 | 0 | 54 | 100 | 13 | ||
Aß = amyloid beta; AD = Alzheimer's disease; FTLD = frontotemporal lobar degeneration; FUS = fused in sarcoma; LBD = Lewy body disease; MND = motor neuron disease; NA = not applicable; TDP = TAR DNA‐binding protein.
*Defined by neuronal loss within anterior horn neurons of the spinal cord and in motor nuclei of the brainstem and the presence of phosphorylated TDP‐43 or FUS neuronal cytoplasmic inclusions in lower motor neurons of the spinal cord and in motor nuclei of the brainstem.