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(a) Generalized pustular eruption on both legs in case 7. (b) Initial response on day 5 after acitretin treatment in case 7. (c) Histopathology shows subcorneal collection of neutrophils, spongiform pustules in the upper layer of the epidermis and infiltration of lymphocytes, neutrophils and rare eosinophils in the upper dermis (hematoxylin–eosin, original magnification ×100).
