Table 3.
Impact of atopic dermatitis severity on patient‐reported mental health, health‐related quality of life and productivity
| Outcome | Mild | Moderate | Severe |
|---|---|---|---|
| HADS, n | 536 | 513 | 395 |
| Total score, mean (SD) | 9.2 (7.0)* | 12.8 (7.4)* | 17.6 (7.9)ߥ |
| HADS‐A score, mean (SD) | 5.5 (4.0)* | 7.3 (4.2)* | 9.4 (4.1)ߥ |
| HADS‐D score, mean (SD) | 3.8 (3.7)* | 5.5 (3.9)* | 8.2 (4.4)ߥ |
| HADS‐A ≥8, n (%) | 135 (25.2)* | 228 (44.4)* | 260 (65.8) |
| HADS‐A ≥11, n (%) | 59 (11.0)* | 118 (23.0)* | 159 (40.3) |
| HADS‐D ≥8, n (%) | 92 (17.2)* | 157 (30.6)* | 222 (56.2) |
| HADS‐D ≥11, n (%) | 33 (6.2)* | 60 (11.7)* | 118 (29.9) |
| DLQI, n | 533 | 511 | 387 |
| Total score, mean (SD) | 5.5 (4.9)* | 10.2 (6.3)* | 16.2 (6.9) |
| Symptoms and feelings, mean (SD) | 2.0 (1.3)* | 3.1 (1.5)* | 4.3 (1.3) |
| Daily activities, mean (SD) | 1.1 (1.3)* | 2.2 (1.6)* | 3.4 (1.7) |
| Leisure, mean (SD) | 0.9 (1.4)* | 1.8 (1.6)* | 3.1 (1.9) |
| Work and school, mean (SD) | 0.4 (0.8)* | 1.0 (1.1)* | 1.5 (1.2) |
| Personal relationships, mean (SD) | 0.6 (1.0)* | 1.3 (1.5)* | 2.5 (1.9) |
| Treatment, mean (SD) | 0.5 (0.7)* | 0.9 (0.8)* | 1.4 (0.9) |
| Productivity in past 4 weeks among part‐/full‐time employees or students, n | 466 | 445 | 321 |
| At least 1 day missed, n (%) | 155 (33.3)* | 233 (52.4)† | 202 (62.9) |
| Total number of days missed related to atopic dermatitis, mean (SD) | 0.9 ± 2.6* | 2.0 ± 4.1* , § | 3.7 ± 5.9¶ |
*P < 0.001 and †P ≤ 0.05 vs. IGA severe.
ߥn = 394. §n = 439; 6 participants who indicated a total number of days exceeding 4 weeks were excluded. ¶n = 307; 14 participants who indicated a total number of days exceeding 4 weeks were excluded.
DLQI, Dermatology Quality of Life Index; HADS, Hospital Anxiety and Depression Scale; HADS‐A, HADS anxiety subscale; HADS‐D, HADS depression subscale; SD, standard deviation.