Table 4.
Relative expression levels of FMR1 following treatment with compounds previously investigated in the clinic for FXS or shown to upregulate FMR1 in non‐neuronal cells
| FMR1 Relative Expression | |||
|---|---|---|---|
| Treatment | Avg (% Control) | StDev | n |
| Control (DMSO) | 100.00 | 20.51 | 3 |
| FXS (DMSO) | 0.08 | 0.02 | 3 |
| Baclofen | 0.44 | 0.09 | 3 |
| 5‐AzaC | 2.75 | 0.74 | 3 |
| Rimonabant | 0.26 | 0.03 | 3 |
| Lovastatin | 2.58 | 4.54 | 3 |
| Metformin | 0.55 | 0.13 | 3 |
| Mavoglurant | 0.60 | 0.09 | 3 |
| MPEP | 0.22 | 0.01 | 3 |
| Valproic Acid | 0.46 | 0.10 | 3 |
| Minocycline | 0.16 | 0.01 | 3 |
| Splitomicin | 0.08 | 0.07 | 3 |