Fig. 8.

PGIA severity and body weight of WT mice after therapeutic regorafenib administration. Mice were immunized with human PG to induce PGIA. Regorafenib or vehicle was administered 5 times a week via oral gavage after the initial signs of arthritis developed. a Mice were monitored and scored for symptoms of arthritis 3 times a week. b AUC of visual arthritis score. c Changes in body weight, calculated as the % of original body weight for each mouse, measured 2 times a week. d AUC of body weight. Values are illustrated as the mean ± SEM or as the percent of baseline (n = 9–10/group, *p < 0.05 vehicle-treated vs 15 mg/kg regorafenib groups; Student’s t test or Mann-Whitney test). AUCs are shown as box plots (center line, median; box limits, upper and lower quartiles; whiskers, maximum and minimum values)