Skip to main content
. Author manuscript; available in PMC: 2020 Jun 26.
Published in final edited form as: Nat Med. 2019 Oct 7;25(10):1576–1588. doi: 10.1038/s41591-019-0590-4

Figure 6. Cell-cell interactions associated with cerebrovascular events.

Figure 6.

(a-c) Heat maps of the top 30 differentially-expressed ligand-receptor interactions between Symptomatic (SYM) and Asymptomatic (ASYM) plaques based on the log2 fold change across ligands and visualized using Clustergrammer. Gene ontology terms associated with the functions of the ligands and receptors are labeled to the left. Ligand-receptor interactions are shown for T cell-T cell interactions (a), T cell-macrophage interactions and macrophage-T cell interactions (b), and macrophage-macrophage interactions (d). Interactions are presented as (ligand-receptor). (d) Schematic illustrating the key innate and adaptive immune functional alterations and main differences in cell-cell communications identified in plaques from ASYM and SYM patients, see text for details.