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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Hum Mutat. 2019 Jul 12;40(9):1424–1435. doi: 10.1002/humu.23800

Figure 1.

Figure 1.

A global overview of the workflow for the Molecular Dynamics based calculation of phenotype alterations due to CHEK2 and CALM1 protein variants, and stability alteration interpretation of the Frataxin protein variants. Calculation of Flexible Segments and Correlation Coefficients are the common steps shared between CHEK2 and CALM1 protein for analyses post MD simulation.