Table 3.
Classification of Frataxin stability values
| Variant | ΔΔG (Exp.) | ΔΔG (Raw) | ΔΔG (Norm.) | Class 1† Exp |
Class 1† Pred. |
Class 2‡ Exp. |
Class 2‡ Pred. |
|
|---|---|---|---|---|---|---|---|---|
| 1. | D104G | 0.26 | −2.5 | −1.7 | 0 | 0 | 0 | 1 |
| 2. | A107V | 0.22 | 28.1 | 1.02 | 0 | 0 | 0 | 0 |
| 3. | F109L | −2.65 | 49.8 | 3.0 | 1 | 0 | 1 | 0 |
| 4. | Y123S | −4.48 | 38.3 | 1.9 | 1 | 0 | 1 | 0 |
| 5. | S161L | −3.44 | −47.7 | −5.8 | 1 | 1 | 1 | 1 |
| 6. | W173C | −9.54 | −68.8 | −7.7 | 1 | 1 | 1 | 1 |
| 7. | S181F | −2.04 | −11.6 | −2.5 | 1 | 1 | 1 | 1 |
| 8. | S202F | −0.69 | 49.1 | 2.9 | 0 | 0 | 0 | 0 |
A threshold of −2.0 kcal/mol† and −1.0 kcal/mol‡ is used to create classes. Label 0 means mutant is stable and 1 otherwise.