TABLE 3.
Summary of IC50 values of abacavir, entecavir, and zidovudine for inhibition of [3H]uridine uptake
A single component IC50 equation was used to generate values for total uptake and ENT2-mediated uptake (+100 nM NBMPR), and the ENT1 component was generated by subtracting the ENT2-mediated component from total uptake. An unpaired t test was used to determine statistical significance. All values are reported as mean ± S.D. of six replicate values (n = 3).
| NRTI | IC50 (ENT1) (mM) | IC50 (ENT2) (mM) |
|---|---|---|
| Abacavir | 0.11 ± 0.02* | 0.22 ± 0.01* |
| Entecavir | 3.05 ± 1.56 | 2.07 ± 0.29 |
| Zidovudine | 2.54 ± 0.26* | 1.64 ± 0.36* |