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. 2020 Jun 24;11:2041731420933407. doi: 10.1177/2041731420933407

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Schematic illustration of cancer stem cell (CSC) models of tumorigenesis and the general features of EMT. (a) CSC models, including the hierarchical and clonal evolution prototypes. CSC subgroups showing self-renegeneration properties as well as capacity to differentiate at the apex of tumorigenesis hierarchy. (b) Schematic of EMT process: cancer cells lose their round, cobblestone-like morphology to become elongated with fibroblast-like morphology. CSCs, cancer stem cells; pCSC, precancerous stem cells; EMT, epithelial-mesenchymal transformation.