Figure 8.
Drug resistance in cancer cells (a) Mechanisms of intrinsic multidrug resistance in cancer cells. (b) Intrinsic relationship between multidrug resistance and physiological factors. Reproduced with permission from Patel et al.165 (2013, Adv Drug Deliv Rev). The susceptibilities of T47D and BT474 cells to 4-hydroxytamoxifen and paclitaxel from different cultivation methods. (c) and (d). (c) The histogram shows absorbance values of T47D and BT474 cells treated with 4-hydroxytamoxifen and paclitaxel from four different scaffolds. (d) Proliferation of T47D and BT474 cells treated with 4-hydroxytamoxifen and paclitaxel cultured in 2D culture were assessed by measuring the absorbance. (e) Proliferation/inhibition curve plots. Reproduced with permission from Rija et al.164 (2017, Sci Adv).