Table 2.

Classification of non-functioning pituitary adenomas, transcription factor, hormonal content, and tumour behaviour.

Tumour type	Transcription factor	Hormone	Behaviour
Gonadotroph	SF1	β-LH, β-FSH, α-SU	—
Corticotroph	T-Pit	ACTH	High-risk
Somatotroph	Pit-1	GH	High-risk
Lactotroph	Pit-1	PRL	—
Pleurihormonal	Pit-1	GH, PRL, TSH, α-SU	High-risk
Double/Triple NFPA	Variable	Variable	—
Null-cell	None	None	—

Abbreviations: ACTH, adrenocorticotropic hormone; PRL, prolactin; TSH, thyroid-stimulating hormone.