Table 1.
Baseline Characteristics of the Study Population.a
| All patients, n = 94 | TACL-ECF, n = 49 | Sorafenib group, n = 45 | P value | |
|---|---|---|---|---|
| Males, n (%) | 70 (74.4) | 37 (75.5) | 33 (73.3) | .818 |
| Age, years (median, range) | 59 (41-80) | 58 (42-76) | 61 (41-80) | .243 |
| Underlying disease, n (%) | .064 | |||
| Chronic hepatitis B | 70 (74.5) | 39 (79.6) | 31 (68.9) | |
| Chronic hepatitis C | 14 (14.9) | 9 (18.4) | 5 (11.1) | |
| Alcoholic liver disease | 4 (4.2) | 1 (2.0) | 3 (6.7) | |
| Others | 6 (6.4) | 0 (0.0) | 6 (13.3) | |
| Child-Pugh class, n (%) | .829 | |||
| A | 62 (66.0) | 33 (67.3) | 29 (64.4) | |
| B | 32 (34.0) | 16 (32.7) | 16 (35.6) | |
| BCLC stage, n (%) | .813 | |||
| B | 22 (23.4) | 12 (24.5) | 10 (22.2) | |
| C | 72 (76.6) | 37 (75.5) | 35 (77.8) | |
| Maximum tumor diameter (cm), n (%) | .153 | |||
| >5 | 51 (54.3) | 23 (46.9) | 28 (62.2) | |
| ≤5 | 43 (45.7) | 26 (53.1) | 17 (37.8) | |
| PV invasion, n (%) | .294 | |||
| Yes | 56 (59.6) | 32 (65.3) | 24 (53.3) | |
| No | 38 (40.4) | 17 (34.7) | 21 (46.7) | |
| Extrahepatic metastases, n (%) | .214 | |||
| Yes | 43 (45.7) | 19 (38.8) | 24 (53.3) | |
| No | 51 (54.3) | 30 (61.2) | 21 (46.7) | |
| AFP (ng/dL), n (%) | .837 | |||
| >200 | 53 (56) | 27 (55.1) | 26 (57.8) | |
| ≤200 | 41 (43.6) | 22 (44.9) | 19 (42.2) | |
| ALT (U/L), (mean ± SD) | 38.61 ± 23.52 | 40.22 ± 25.39 | 36.84 ± 21.45 | .489 |
| Platelets (×1000/mm3), mean ± SD | 145 ± 101 | 126 ± 73 | 165 ± 123 | .059 |
| Bilirubin (mg/dL), (mean ± SD) | 1.20 ± 0.69 | 1.14 ± 0.63 | 1.26 ± 0.75 | .364 |
| Albumin (g/dL), (mean ± SD) | 3.38 ± 3.40 | 3.27 ± 0.67 | 3.50 ± 0.47 | .056 |
| PT INR, (mean ± SD) | 1.18 ± 0.14 | 1.19 ± 0.15 | 1.16 ± 0.12 | .351 |
| Creatinine (mg/dL), (mean ± SD) | 0.74 ± 0.19 | 0.75 ± 0.19 | 0.72 ± 0.20 | .451 |
Abbreviations: AFP, α-fetoprotein; BCLC, Barcelona Clinic Liver Cancer; PT INR, prothrombin time international normalized ratio.
a The χ2 test for categorical variables and Student t test for continuous variables. Data are presented as the mean ± SD, median (range in parentheses) or number of patients (percentages in parentheses).