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. 2020 Jul;374(1):200–210. doi: 10.1124/jpet.119.264069

Fig. 4.

Fig. 4.

LY354740 (4 mg/kg, i.p.) did not alter the IRT distribution induced by saline (sal) or fluoxetine (fluox) (2.5–10 mg/kg) in rats (n = 8) performing under a DRL 72-s schedule. The IRT distribution is in two panels displaying the effects of saline (open symbol) or fluoxetine, demonstrating a cohesive dose-related rightward shift induced by fluoxetine (A). The opposite rightward and leftward shift associated with LY354740 (LY) for the fluoxetine 2.5- and 10-mg/kg doses, respectively, resulted in a blunting of the overall fluoxetine rightward shifts in the IRT distribution (B).