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. Author manuscript; available in PMC: 2021 Mar 18.
Published in final edited form as: Neuron. 2020 Jan 8;105(6):975–991.e7. doi: 10.1016/j.neuron.2019.12.015

Figure 2. Validation of AD-related proteins by profiling individual human samples in both Banner Sun and Mount Sinai cohorts.

Figure 2.

(A) Analysis of Banner Sun individual cohort. A total of 49 Banner Sun individual cases were measured with TMT-LC/LC-MS/MS in 5 batches.

(B) Analysis of 80 human cases from Mount Sinai cohort. After removing outliers, 62 cases (23 controls and 39 AD cases) were analyzed.

(C) Bioinformatics pipeline for validating DE proteins by individual cases from two cohorts.

(D) Validated DE proteins in three datasets (Banner Sun pooled samples, Banner Sun individual samples, and Mount Sinai individual samples). Each protein is represented by a colored box after log2 Z-score conversion. The heat map on the far right indicates consistent (up or down) or inconsistent changes between proteome and transcriptome.

(E) Analysis of CSF samples from Banner Sun cohort. After removing outliers, 5 controls and 8 AD cases were analyzed.

(F) Consistent protein changes of 8 proteins in AD brain tissue and CSF.

See also Figure S4 and Data S4.