Table 1.
Baseline Characteristics of Full Cohort and by Lines of Therapy
| Patient Characteristics | Category | GBM Cohort (N = 4308) |
|---|---|---|
| Age at diagnosis, n (%), y | 66-70 | 1259 (29.2) |
| 71-75 | 1175 (27.3) | |
| 76-80 | 1021 (23.7) | |
| 80+ | 853 (19.8) | |
| Sex, n (%) | Male | 2344 (54.4) |
| Female | 1964 (45.6) | |
| Race/Ethnicity, n (%) | Non-Hispanic white | 3797 (88.1) |
| Non-Hispanic black | 158 (3.7) | |
| Hispanic | 231 (5.4) | |
| Other | 122 (2.8) | |
| Marital status at diagnosis, n (%) | Single (never married) | 302 (7.0) |
| Married | 2746 (63.7) | |
| Separated/Divorced/Widowed | 1126 (26.1) | |
| Unknown | 134 (3.1) | |
| Census location, n (%) | West | 1872 (43.5) |
| South | 985 (22.9) | |
| Northeast | 905 (21.0) | |
| Midwest | 546 (12.7) | |
| Urban location, n (%) | Rural | 476 (11.0) |
| Urban | 3832 (89.0) | |
| Charlson Comorbidity Index, n (%) | 0 | 2239 (52.0) |
| 1 | 1125 (26.1) | |
| 2 | 492 (11.4) | |
| 3+ | 452 (10.5) | |
| Poor performance status, n (%) | Yes | 1097 (25.5) |
| Laterality, n (%) | Right side | 1873 (43.5) |
| Left side | 1750 (40.6) | |
| Unknown or midline | 685 (15.9) | |
| Tumor extension, n (%) | Supratentorial tumor confined to 1 side | 3069 (71.2) |
| Confined to brain or meninges | 243 (5.6) | |
| Confined to ventricles | 161 (3.7) | |
| Tumor crosses the midline | 596 (13.8) | |
| Unknown | 83 (1.9) | |
| Other | 156 (3.6) | |
| Topographic location of tumor, n (%) | Frontal lobe | 1185 (27.5) |
| Temporal lobe | 1136 (26.4) | |
| Parietal lobe | 729 (16.9) | |
| Overlapping sites | 613 (14.2) | |
| Cerebrum (except lobes) | 395 (9.2) | |
| Occipital lobe | 223 (5.2) | |
| Cerebellum | 26 (0.6) | |
| Tumor size, n (%) | Less than 50 mm | 723 (16.8) |
| Between 50 and 70 mm | 2713 (63.0) | |
| Greater than 70 mm | 210 (4.9) | |
| Missing | 662 (15.4) | |
| Diagnosis year, n (%) | 2007 | 643 (14.9) |
| 2008 | 584 (13.6) | |
| 2009 | 619 (14.4) | |
| 2010 | 592 (13.7) | |
| 2011 | 581 (13.5) | |
| 2012 | 637 (14.8) | |
| 2013 | 652 (15.1) |
Abbreviation: GBM, glioblastoma.