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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Ann Allergy Asthma Immunol. 2019 Nov 28;124(2):135–142. doi: 10.1016/j.anai.2019.11.024

Figure 3.

Figure 3.

Three forms of allergic sensitization that occur via the skin. (A) Peanut allergy often develops in children with underlying eczema who are exposed to peanut allergens via the skin. Subsequent oral exposure can lead to allergic reactions. (B) Sensitization to α-Gal is caused by tick bites and generally occurs in subjects without eczema or other inflammatory skin diseases. This reflects that ticks can have a prolonged feed while attached to skin and also have salivary factors that act as Th-2-promoting adjuvants. (C) Venomous insect stings lead to sensitization and also can lead to allergic reactions on subsequent exposures via the skin.