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. 2020 Jun 19;11:925. doi: 10.3389/fphar.2020.00925

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Copyright © 2020 Saika, Matsuzaki, Kobayashi, Ideguchi, Nakamura, Kishioka and Kiguchi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relief of mechanical allodynia after PSL by intrathecal CNO in male CX3CR1-hM4Di mice. The mice were subjected to PSL, and CNO (20 nmol) or Veh was intrathecally (i.t.) administered after pain assessment as indicated by arrows. The 50% paw withdrawal threshold was assessed by the up–down method using the von Frey test. (A, B) Effect of CNO on the 50% paw withdrawal threshold in the ipsilateral side of male CX3CR1-hM4Di and Control-hM4Di mice after PSL. (C) No effect of CNO on mechanical allodynia in the ipsilateral side of female CX3CR1-hM4Di mice after PSL. Data are presented as mean ± S.E.M. n = 4-9. p***< 0.001, p* < 0.05 vs Veh.