Table 1.

Resolvins and their functions on immune cells.

Immune cells	Resolvin D-series					Resolvin E-series
	RvD1	RvD2	RvD3	RvD4	RvD5	RvE1	RvE2	RvE3	RvE4	References
PMNs migration infiltration	↓	↓	↓	↓	↓	↓	↓	↓	↓	(23, 26, 28, 30, 33–39)
Mediators	↑IL-10 ↓LTB4	↓IL-1β ↓IL-6 ↓IL-17 ↓IL-23 ↓TNFα ↓LTB4 ↓↑IL10	↓IL-6 ↓LTB4 ↑IL-10			↓IL-1β↓IL-6↓TNFα	↑IL-10	↓IL-4↓IL-5↓IL-13↓IL-23		(24, 26, 28, 34, 35, 37, 40–44)
Mφ efferocytosis	↑	↑	↑	↑	↑	↑	↑		↑	(23, 28, 34, 37, 38, 41, 45)
Mφ polarization	↑M2	↑M2								(46–49)
DCs						↓Migration ↓IL-12 ↓IL-23	↓IL-23	↓IL-23		(29, 35)
T cells	↓CD4+T ↓Th1 ↓Th17 ↓IFN-ɤ ↓IL-17 ↓CD8+T ↑Treg	↓CD4+T↓Th1↓Th17↓IFN-ɤ ↓IL-17↓CD8+T↑Treg				↓CD4+T ↓ IL-4 ↓IFN-ɤ ↓CD8+T				(44, 50, 51)
B cells	↑IgM ↑IgG ↓IgE									(52–54)

DCs, dendritic cells; IL, interleukin; Ig, immunoglobulin; IFN-ɤ, interferon-gamma; LTB₄, leukotriene B₄; Mφ, macrophages; PMNs, polymorphonuclear leukocytes; RvD, resolvin D; RvE, resolvin E; Th, T helper; TNF-α tumor necrosis factor alpha; Treg, T regulatory cell.