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. 2020 Jun 19;11:930. doi: 10.3389/fphar.2020.00930

Figure 4.

Figure 4

Effects of Hydrostatin-SN1 (dosage of 50 μg/kg) on pathological parameters of colitis in IL-10 knockout mice. (A) The workflow shows the design of this experiment. The weights of the mice treated with infliximab or Hydrostatin-SN1 were recorded as the initial weight. (B) Greater body weight gain was observed in the IL-10 knockout mice group treated with Hydrostatin-SN1 and infliximab. (C) The disease activity index was decreased in the groups of IL-10 knockout mice treated with Hydrostatin-SN1 and infliximab. (D) The spleen weight index was calculated for each group, and Hydrostatin-SN1 reduced the spleen weight index in IL-10 knockout mice. (E) The mRNA expression of inflammatory cytokines in the colon. mRNA expression levels were determined by real-time PCR, using specific primers for IL-1β. (F) Microscopic images of the colons are shown by hematoxylin–eosin staining. Magnification ×200. Values represent the mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001 of Hydrostatin-SN1-treated group vs. the IL-10 KO group.