Table 2.

Effect of tPA treatment on stroke outcomes and mortality.

Patients number	Sex-specific outcomes	References
2,178	Women benefit more from tPA compared with men (p = 0.04) at 90 days	(69)
1,272	Reduced mortality in women (p = 0.023) and improved Barthel score	(70)
887	Women had a better outcome in the age group 51–60 years old compared with men (OR 0.38; 95% CI [0.15–0.96]. In the age group >80 years old, men had a better outcome than women (OR 2.69, 95% CI [1.21–5.96]).	(71)
25,777	No difference between sexes in functional outcome (OR 1.03; 95% CI [0.97–1.09]; p = 0.39), males had higher risk of mortality (OR 1.19; 95% CI [1.10–1.29]; p = 0.00003).	(67)
9,914	No sex difference in outcome at 3 months (adjusted OR for women 1.41; 95% CI [0.76–2.60]), and in 90-days mortality (adjusted OR 1.38; 95% CI [0.59–3.19]).	(72)
1,110	No difference in NIHSS score and mortality between men and women	(73)
156	At day 90, no significant sex difference in functional outcome (50.9% of women compared with 57.0% of men, p = 0.5), favorable functional outcome (61.4% of women compared with 68.8% of men, p = 0.38)	(74)
1,391	No effect of sex was seen on outcome (OR 1.04; CI [0.76–1.43]); or mortality (OR 1.13; CI [0.73–1.73]).	(75)