Table 2.
Biochemical patterns of patients with metamizole‐induced liver injury: at initial presentation and peak values
| Group of metamizole‐induced DILI cases | n | AST (initial) | ALT (initial) | ALP (initial) | GGT (initial) | Total bilirubin (initial) | AST (peak) | ALT (peak) | ALP (peak) | GGT (peak) | Total bilirubin (peak) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| < 50 U/L (male) <35 U/L (female) | < 50 U/L (male) <35 U/L (female) | < 129 U/L (male) < 104 U/L (female) | < 65 U/L (male) < 38 U/L (female) | <1.2 mg/dL | < 50 U/L (male) <35 U/L (female | < 50 U/L (male) <35 U/L (female) | < 129 U/L (male) <104 U/L (female) | < 65 U/L (male) <38 U/L (female) | <1,2 mg/dL | ||
| All | 23 | 574 (39–4172) | 779 (64–3532) | 131 (42–578) | 196 (10–1345) | 1.9 (0.3–21.1) | 1033 (514–4172) | 1391 (683–3636) | 176 (85–854) | 300 (61–2165) | 3,8 (0.7–40.7) |
| Recovery | 21 | 574 (39–2774) | 784 (64–3532) | 131 (66–578) | 205 (38–1345) | 1.9 (0.3–21.1) | 864 (335–2774) | 1374 (683–3636) | 153 (85–854) | 306 (61–2165) | 3.7 (0.7–40.7) |
| ALF and LTX | 2 | 2115 (57–4172) | 1822 (69–3574) | 104 (42–166) | 69 (10–128) | 4.3 (0.3–8.4) | 3085 (1998–4172) | 3538 (3502–3574) | 235 (227–243) | 270 (239–300) | 27.5 (24.5–30.5) |
ALF, acute liver failure; ALT, alanine transaminase; ALP, alkaline phosphatase; AST; aspartate transaminase; DILI, drug‐induced liver injury; GGT, γ‐glutamyltransferase; LTX, liver transplantation.