Table 1.
Demographic and Clinical Characteristics of 145 Ugandan Children With Cerebral Malaria (CM) in Whom Admission Cerebrospinal Fluid (CSF) Tau Concentrations Were Measured Compared With 124 Uganda Children With CM in Whom CSF Tau Concentrations Were Not Measured
| Characteristic | CSF Tau Measured (n = 145a) | CSF Tau Not Measured (n = 124a) | P Valueb |
|---|---|---|---|
| Age, y, median (IQR) | 3.36 (2.63–4.19) | 3.63 (2.29–5.22) | .48 |
| Female sex, % (no.) | 40.69 (59) | 41.13 (51) | .94 |
| HIV status, % positive (no./No.) | 2.13 (3/141) | 1.89 (2/106) | .89 |
| Hemoglobin, g/dL, median (IQR) | 6.3 (4.9–8.5) | 7 (5.65–8.85) | .06 |
| Glucose, mmol/L, median (IQR) | 6.6 (5.1–9.2) | 6.5 (4.65–8.65) | .55 |
| Parasite density, parasites/µL, median, (IQR), No. | 53 680 (13 980–294 660), 141 | 42 560 (9760–209 220), 121 | .44 |
| Malaria retinopathy present, % (no./No.) | 68.97 (100/145) | 60.91 (67/110) | .18 |
| Acute kidney injury, % (no./No.) | 50.00 (70/140) | 35.83 (43/120) | .02 |
| Mortality, % (no.) | 5.52 (8) | 20.97 (26) | <.001 |
| Total hours in coma, median (IQR), no. | 60 (33–83), 137 | 45.5 (27–80), 98 | .08 |
| Convulsions during hospitalization, % (no.) | 60.00 (87) | 45.97 (57) | .02 |
| No. of convulsions during hospitalization, median (IQR) | 1 (0–2) | 0 (0–2) | .10 |
| Neurologic deficits at discharge, %, (no./No.) | 39.26 (53/135) | 30.93 (30/97) | .19 |
| Neurologic deficits, 6-mo follow-up, %, (no./No.) | 6.11 (8/131) | 3.23 (3/93) | .32 |
| Neurologic deficits, 12-mo follow-up, %, (no./No.) | 3.82 (5/131) | 2.17 (2/92) | .49 |
| Neurologic deficits, 24-mo follow-up, %, (no./No.) | 3.08 (4/130) | 2.22 (2/90) | .70 |
Abbreviations: CSF, cerebrospinal fluid; HIV, human immunodeficiency virus; IQR, interquartile range.
aFor variables for which the no. is less than the total No. listed for the group, the numbers for that variable and group are noted in the table.
bWilcoxon rank-sum test for continuous variables, χ2 test for categorical variables.