Table 1.
Baseline characteristics of resected incident, colorectal cancers with known KRAS status in National Cancer Database diagnosed during 2010–2014
| KRAS statusa | ||||||
|---|---|---|---|---|---|---|
| Wild Type, n (%) | Mutated, n (%) | P value | ||||
| Total | 28423 | (62) | 17338 | (38) | 45761 | |
| Age | 0.016 | |||||
| <65 year | 14931 | (53) | 9309 | (54) | 24240 | |
| 65+ year | 13492 | (47) | 8029 | (46) | 21521 | |
| Sex | <0.001 | |||||
| Male | 15159 | (53) | 8868 | (51) | 24027 | |
| Female | 13264 | (47) | 8470 | (49) | 21734 | |
| Tumor deposit | 0.001 | |||||
| None | 19126 | (68) | 11368 | (66) | 30494 | |
| Yes | 7076 | (25) | 4536 | (27) | 11612 | |
| NA | 1835 | (7) | 1200 | (7) | 3035 | |
| Microsatellite Instability (MSI) | <0.001 | |||||
| Stable/Low | 9116 | (81) | 5533 | (86) | 14649 | |
| Unstable/High | 2112 | (19) | 905 | (14) | 3017 | |
| Location | 0.006 | |||||
| Colon | 24778 | (87) | 15266 | (88) | 40044 | |
| Rectum | 3645 | (13) | 2072 | (12) | 5717 | |
| Tumor stage | <0.001 | |||||
| I-II | 8806 | (33) | 4575 | (28) | 13381 | |
| III-IV | 17837 | (67) | 11722 | (72) | 29559 | |
| Tumor grade | <0.001 | |||||
| Low | 19470 | (72) | 13016 | (79) | 32486 | |
| High | 7696 | (28) | 3501 | (21) | 11197 | |
| Charlson-Deyo Score | 0.55 | |||||
| 0 | 20811 | (73) | 12775 | (74) | 33586 | |
| 1 | 5752 | (20) | 3452 | (20) | 9204 | |
| 2 | 1860 | (7) | 1111 | (6) | 2971 | |
| Race | <0.001 | |||||
| NH White | 21722 | (79) | 12316 | (73) | 34038 | |
| NH Black | 2816 | (10) | 2506 | (15) | 5322 | |
| Hispanic | 1795 | (7) | 1260 | (8) | 3055 | |
| Others | 1218 | (4) | 716 | (4) | 1934 | |
| Received chemotherapy | <0.001 | |||||
| No | 7743 | (29) | 4169 | (26) | 11912 | |
| Yes | 18747 | (71) | 12013 | (74) | 30760 | |
| Received radiotherapy | 0.098 | |||||
| No | 24490 | (87) | 15024 | (88) | 39514 | |
| Yes | 3649 | (13) | 2133 | (12) | 5782 | |
MSI, microsatellite instability; NH, Non-Hispanic; P, Chi-square test for associations; NA, not available;
a
Sum of the subtotals may not be equal to the grand total due to missing data in some strata.