Table 2.
Factors associated with tumor deposit status (present vs absent) of incident colorectal cancers in National Cancer Database diagnosed during 2010–2014
| OR | 95% CI | P | |
|---|---|---|---|
| All tumor | |||
| MSI (Unstable/High vs Stable/Low) | 0.84 | (0.75 to 0.95) | 0.004 |
| KRAS (Mutated vs Wild type) | 1.11 | (1.02 to 1.20) | 0.015 |
| Location (Rectal vs Colonic) | 1.14 | (0.99 to 1.30) | 0.064 |
| Age (65+ vs <65 year) | 0.85 | (0.78 to 0.92) | <0.001 |
| Pathologic stage (III-IV vs I-II) | 14.44 | (12.51 to 16.66) | <0.001 |
| Tumor grade (High vs Low) | 1.58 | (1.45 to 1.73) | <0.001 |
| Early stage tumor (stage I-II) | |||
| MSI (Unstable/High vs Stable/Low) | 0.87 | (0.61 – 1.25) | 0.454 |
| KRAS (Mutated vs Wild type) | 1.49 | (1.13 – 1.97) | 0.005 |
| Location (Rectal vs Colonic) | 1.13 | (0.77 – 1.65) | 0.545 |
| Age (65+ vs <65 year) | 0.71 | (0.54 – 0.95) | 0.020 |
| Tumor grade (High vs Low) | 1.83 | (1.30 – 2.57) | 0.001 |
| Late stage tumor (stage III-IV) | |||
| MSI (Unstable/High vs Stable/Low) | 0.84 | (0.74 – 0.95) | 0.004 |
| KRAS (Mutated vs Wild type) | 1.08 | (0.99 – 1.17) | 0.100 |
| Location (Rectal vs Colonic) | 1.14 | (0.98 – 1.31) | 0.080 |
| Age (65+ vs <65 year) | 0.86 | (0.79 – 0.94) | 0.001 |
| Tumor grade (High vs Low) | 1.57 | (1.43 – 1.72) | <0.001 |
P of multivariable logistic regression analysis; MSI, microsatellite instability; OR, odds ratio; CI, confidence intervals. Race, sex and Charlson-Deyo Score were not linked to tumor deposit status.