Table 4.

Factors associated with overall survival of incident colorectal cancers in National Cancer Database diagnosed during 2010–2014 by tumor pathologic stage

	HR	95% CI	Pa
Stage I-IIb
MSI (Unstable/High vs Stable/Low)	0.92	(0.77 – 1.11)	0.397
KRAS (Mutated vs Wild type)	1.32	(1.14 – 1.54)	<0.001
Tumor deposit (Present vs absent)	1.28	(1.09 – 1.51)	0.002
Stage III-IVc
MSI (Unstable/High vs Stable/Low)	0.98	(0.89 – 1.08)	0.689
KRAS (Mutated vs Wild type)	1.18	(1.10 – 1.27)	<0.001
Tumor deposit (Present vs absent)	1.42	(1.35 – 1.50)	<0.001

MSI, microsatellite instability.

^aP of multivariate Cox regression analyses adjusted for age, tumor grade, pathologic stage, Charlson-Deyo score, chemotherapy status, radiotherapy status and race.

^bChemotherapy status included as time-varying covariate.

^cTumor grade, age and chemotherapy status included as time-varying covariates.