Table 3.

Multivariate analysis for overall survival of clinical and lung function parameters.

	Hazard ratios for overall survival
	n	HR	95% CI	p value
FEV1 < 70% of predicted	18	2.47	1.20, 5.06	0.02
DLCOc SB < 60% of predicted	35	1.87	1.15, 3.03	0.02
Karnofsky index ≤ 80%	92	1.70	1.11, 2.58	0.02
HCT-CI score liver	51	1.69	1.04, 2.74	0.03
Age < 55 years	63	0.51	0.30, 0.88	0.02
Conditioning with FTM	105	1.31	0.85, 2.58	0.21

Clinical factors (Supplementary Table 2) with a p value < 0.1 in univariate analysis were included in the multivariate analysis with conditioning protocol as hypothesis covariate. Multivariate analysis following backward selection was performed using the Cox proportional hazards regression model.

HCT-CI hematopoietic cell transplantation comorbidity index, DLCOcSB diffusion capacity of carbon monoxide adjusted for hemoglobin level, FEV1 forced expiratory volume in 1s, HR hazard ratios, CI confidence intervals, FTM fludarabine, thiotepa, melphalan.