Table 3.

Heart Ultrasound Data

		General Cardiac Function
		Vehicle	Lo PM	Hi PM	Linear (p < 0.05)
HR	Beats/minute	364 ± 16	338 ± 18 *	368 ± 22 †	No
ESV	Microliters	71 ± 19	84 ± 22	103 ± 23 *	↑
EDV	Microliters	315 ± 24	324 ± 40	358 ± 43	↑
SV	Microliters	244 ± 25	239 ± 33	254 ± 26	No
CO	mL/minute	89 ± 10	81 ± 13	94 ± 7	No
EF	%	78 ± 6	74 ± 6	71 ± 4	↓
FS	%	48 ± 6	45 ± 6	42 ± 3	↓
			Mean ± SD
		Pulmonary Artery Blood Flow
PAT/PET	:	0.42 ± 0.07	0.45 ± 0.03	0.49 ± 0.06 *	↑
			Mean ± SD
		Transmitral Blood Flow
Performance	Tei index	0.45 ± 0.1	0.47 ± 0.1	0.47 ± 0.1	No
IVCT	%CC	7.1 ± 2.3	7.1 ± 3.1	7.8 ± 2.2	No
AET	%CC	38.4 ± 2.5	37.2 ± 4.4	39.8 ± 3.8	No
IVRT	%CC	10.3 ± 1.1	10.0 ± 1.0	10.1 ± 0.6	No
			Mean ± SD

^*p<0.05 vs. Vehicle

^†p<0.05 vs. Lo PM by ANOVA with Tukey’s post-test, ↑increasing or ↓decreasing linear trend analysis (p<0.05)

Abbreviations: HR – heart rate, ESV – end systolic volume, EDV – end diastolic volume, SV – stroke volume, CO – cardiac output, EF – ejection fraction, FS – fractional shortening, PAT – pulmonary artery blood flow acceleration time, PET – pulmonary artery blood flow ejection time, IVCT – isovolumic contraction time, AET – aortic ejection time, IVRT – isovolumic relaxation time, %CC – percent of cardiac cycle