Table 4.

Cost-effectiveness of Clostridioides difficile Infection Treatment Strategies

Strategy No.	Nonsevere	Severe	First Recurrence	Second or Later Recurrence	Cost	Incremental Cost	Effectiveness, QALYs	Incremental Effectiveness, QALYs	ICER, $/QALY
3	Metronidazole	Vancomycin	Vancomycin	Vancomycin	$64 509	…	12.280	…	…
1	Vancomycin	Vancomycin	Vancomycin	Vancomycin	$64 692	$183	12.352	0.072	2537
25	Vancomycin	Vancomycin	Vancomycin	Vancomycin + rifaximin	$64 917	$225	12.406	0.054	4208
37	Vancomycin	Vancomycin	Vancomycin	FMT	$65 125	$208	12.426	0.020	10 383
43	Vancomycin	Vancomycin	Fidaxomicin	FMT	$65 411	$286	12.442	0.016	27 428
44	Fidaxomicin	Vancomycin	Fidaxomicin	FMT	$65 889	$478	12.451	0.009	31 751

All costs are given as US dollars.

Abbreviations: FMT, fecal microbiota transplantation; ICER, incremental cost-effectiveness ratio; QALY, quality-adjusted life-year.