Figure 1.

Impact of age of initiation of effective cART on the size of the viral reservoir, measured by quantitative assay of HIV-1 DNA in PBMCs (A), copies of HIV-1 RNA produced by prostratin analogue stimulated CD4+ T-cells (B), and quantitative HIV-1–specific serologic response in children with perinatally acquired HIV-1 infection (C). The horizontal lines correspond to the median and IQR. The significant and nonsignificant differences between groups were retained in the analysis adjusted for biological sex, CD4% nadir, VL peak, and virologic blips (data not shown). Abbreviations: cART, combination antiretroviral therapy; HIV-1, human immunodeficiency virus–1; IQR, interquartile range; PBMCs, peripheral blood mononuclear cells; VL, viral load.