Table 2.
Reservoir Size According to Age of Effective Combination Antiretroviral Therapy Initiation
| Parameter | Group 1 (n = 10) | Group 2 (n = 30) | Group 3 (n = 29) | P Valuea | |
|---|---|---|---|---|---|
| HIV-1 DNAb | Median (IQR) | 10.0 (10.0, 18.0) | 117.2 (57.5, 247.5) | 77.3 (29.8, 170.1) | <.001 |
| % undetectable | 70.0% | 13.3% | 14.3% | <.001 | |
| Cell-free HIV-1 RNAc | Median (IQR) | 3.0 (1.2, 12.0) | 5.5 (2.4, 21.7) | 14.7 (3.4, 63.6) | .17 |
| % undetectable | 20.0% | 13.3% | 13.8% | .81 | |
| Ultrasensitive VLd | Median (IQR) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | .67 |
| % negative | 90.0% | 81.5% | 79.2% | .91 | |
| Quantitative serology (S/CO) | Median (IQR) | 3.4 (0.2, 22.4) | 145.9 (12.4, 348.6) | 141.8 (45.9, 303.9) | .002 |
| % negative | 30.0% | 0% | 0% | .002 |
Abbreviations: HIV-1, human immunodeficiency virus–1; IQR, interquartile range; PBMC, peripheral blood mononuclear cell; S/CO, signal-to-cutoff ratio; VL, viral load
aThe unadjusted P values are presented. In the regression analysis adjusting for biological sex, CD4% nadir, VL peak, and virologic blips, no significant changes to the results were observed. Minor adjusted P value changes were in the mean log10 HIV-1 DNA (P = .001), percent undetectable HIV-1 DNA (P = .018), and mean log10 S/CO (P < .001).
bExpressed as copies per 106 PBMC; <10 copies per 106 PBMC are considered undetectable.
cExpressed as copies of HIV RNA produced per 106 stimulated CD4+ T-cells; <1 copy per 106 CD4+ T-cells is considered undetectable.
dLevel of detection set at 5 copies/mL.