Fig 5. Clinical tradeoff between additional VTE and major bleeding in a hypothetical cohort in 1,000 VTE patients.

The x-axis gives the threshold above which prolonged anticoagulant treatment is recommended, based upon annualized risk estimates from the Vienna Prediction Model. The y-axis gives the number of additional VTE and major bleeding events induced depending on the threshold above which prolonged anticoagulant treatment is recommended. The bar below the graph illustrates the proportion of patients treated with anticoagulants depending on the threshold above which prolonged anticoagulant treatment is prescribed. Major bleeding rates are as expected for prolonged non-vitamin K antagonist oral anticoagulant treatment, based upon available trial evidence. VTE, venous thromboembolism.